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A multicenter non-inferiority open-labeled randomized controlled trial of oral amoxicillin-clavulanate (50 mg/kg/day divided 3 times a day for 10 days) compared to initial parenteral treatment with ceftriaxone (50 mg/kg/day as a single daily dose for 3 days) followed by oral amoxicillin-clavulanate (for 7 days) for children < 6 years of age with acute pyelonephritis and no anatomic urogenital tract abnormalities was conducted from 2000 to 2004 among 502 children 1 month to 7 years of age in 28 primary care practices in northern Italy.

Oral Antibiotics for Pyelonephritis in Children