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The present study indirectly tested the hypothesis that estrogen exposure is neuroprotective by studying the risk of dementia in women who underwent oophorectomy premenopausally. All women residing in Olmstead, MN, from 1950 to 1987 who underwent unilateral or bilateral oophorectomy were followed through death or end of study (staggered from 2001 to 2006).

Increased Risk of Cognitive Impairment or Dementia in Women Who Underwent Oophorectomy before Menopause