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Beginning in 2000, the University of Pittsburgh Medical Center (UPMC) Presbyterian experienced a marked increase in hospital-acquired C. difficile infection, from 2.7 infections per 1000 discharges (0.46 per 1000 patient days) in the 2 preceding years to 7.2 per 1000 discharges (1.17 per 1000 patients days).

Multi-Faceted Approach to Hypervirulent C. difficile Control