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A prospective, multi-center, double-blind, placebo-controlled, randomized clinical trial was conducted of oral supplementation of bovine lactoferrin (BLF) alone or in combination with the probiotic Lactobacillus rhamnosus GG (LGG) to reduce the incidence of late onset sepsis (> 72 hours after birth) in very low birth-weight (VLBW) (< 1,500 g) newborns.

Oral Lactoferrin Supplementation to Prevent Late-Onset Neonatal Sepsis