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The efficacy of percutaneous closure of the LAA with the WATCHMAN® left atrial closure device was found to be non-inferior to that of standard warfarin therapy for prevention of stroke, cardiovascular death, and/or systemic embolism and, therefore, the device might provide an alternative strategy to chronic warfarin therapy for stroke prophylaxis in patients with non-valvular atrial fibrillation.

Percutaneous Closure of Left Atrial Appendage vs Warfarin Therapy