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Mechanism of Action: The mechanism of action is unknown for both drugs, but is hypothesized to involve prostaglandin inhibition, leading to constriction of ductus arteriosus. Indomethacin is predicted to have additional or more extensive actions that increase the chances of cerebral, renal, and gastrointestinal (GI) adverse reactions.

Drug Criteria & Outcomes: NeoProfen Formulary Evaluation