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Summarizing adverse events reported to the FDA, 6 definite cases of intravascular hemolysis (hemoglobinuria/hemoglobinemia and/or DIC) are detailed after administration of anti-D IGIV (WinRho). Several patients developed intravascular hemolysis after previously uncomplicated anti-D IGIV. Five patients were adults and all died. This study not only demonstrates that potentially fatal acute intravascular hemolysis may occur after anti-D IGIV and the importance of post-marketing surveillance.

DIC and Hemolysis after WinRho Treatment for ITP