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Iplex® (mecasermin rinfabate) and Increlex® (mecasermine) are two recently approved agents for the treatment of short stature in pediatric patients. Mecasermin rinfabate is composed of human insulin-like growth factor-1 (IGF-1) and human insulin-like growth factor-binding protein-3 (IGFBP-3).

Drug Criteria & Outcomes: Iplex® and Increlex® Formulary Evaluation