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A total of 1,763 HIV-1 serodiscordant couples in nine countries with the infected partner having CD4+ counts of 350-500/mL were randomized 1:1 to early (immediate) vs. delayed (CD4+ had declined to ¡Ü 250/mL or after development of an AIDS-related illness) antiretroviral therapy of the infected partner.

Abstract & Commentary: Prevention of HIV Infection in Serodiscordant Couples with Early Antiretroviral Therapy