After a review of available evidence, the U.S. Preventive Services Task Force has issued new guidance stating that screening for syphilis infection in asymptomatic, nonpregnant persons at increased risk for infection provides substantial benefits.

  • The number of cases of primary and secondary syphilis has been increasing since 2000. In 2014, 19,999 cases (6.3 cases per 100,000 persons) of primary and secondary syphilis were reported in the United States.
  • Treatment of syphilis is vital because, if left untreated, syphilis can cause damage to the nervous system, the heart, and other organs.