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Editor's note: In this issue we begin a two-part series on the national epidemic of Clostridium difficile (C. diff) with an overview of the current situation and a specific focus on challenges to hand hygiene. Look for the June 2010 issue of Hospital Infection Control & Prevention for the latest findings and recommendations on C. diff testing, discontinuing isolation and the difficult issue of environmental cleaning.

Hand hygiene ineffectiveness, confusion undercut response to deadly C. diff epidemic