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Based on a patient’s lipoprotein abnormality, the algorithm described in this review begins with achievable, practical therapeutic lifestyle changes and then adds pharmacologic agents in stepwise fashion to address abnormalities of LDL cholesterol, triglycerides, and HDL cholesterol. While the approach is aggressive, it is not based on driving lipid levels to extremely low levels. While some of the lipid targets appear less stringent than conventional wisdom would suggest (eg, accepting an LDL cholesterol target of 130 mg/dL), the approach is in compliance with the spirit and letter of national guidelines.

A Critical Appraisal of Dyslipidemia Therapy