Ibuprofen and Paracetamol Have the Same Antipyretic ActivitySource: Vauzelle-Kervroëdan F, et al. Equivalent antipyretic activity of ibuprofen and paracetamol in febrile children.J Pediatr1997;131:683-687. The antipyretic activity of ibuprofen was compared in an equivalence study with paracetamol in the same formulation by Vauzelle-Kervroëdan and associates from several hospitals in Paris.1Para-cetamol is a non-steroidal anti-inflammatory drug widely used in Europe and Asia which is similar to acetaminophen. The study was conducted as a double-blind multicenter trial, with random allocation of the treatments. One hundred sixteen children of both sexes, ages 4.1 ± 2.6 years, who had a fever related to an infectious disease and a mean temperature of 39°C ± 0.5°C at the time of inclusion, were studied. They were treated with single doses of either 10.3 ± 1.9 mg/kg of ibuprofen or 9.8 ± 1.9 mg/kg of paracetamol. The subject's rectal temperature was regularly monitored for six hours.

The statistical analysis of the results confirmed that ibuprofen and paracetamol are equivalent with respect to the following criteria: 1) time elapsed between dosing and the lowest temperature: 3.61 ± 1.34 hours for ibuprofen and 3.65 ± 1.47 hours for paracetamol (95% confidence interval [CI] of the difference; -0.48, +0.56); 2) extent of the temperature decrease: 1.65°C ± 0.80°C for ibuprofen and 1.50°C ± 0.61°C for paracetamol (95% CI of the difference; -0.41, +0.11); 3) rate of temperature decrease: 0.52 ± 0.32°C/h for ibuprofen and 0.51°C ± 0.38°C/h for paracetamol (95% CI of the difference; -0.45, +0.55); and 4) duration of temperature below 38.5°C: 3.79 ± 1.33 hours for ibuprofen and 3.84 ± 1.22 hours for paracetamol (95% CI of the difference; -0.14, + 0.12). -
 

Latex Allergy

Source: Reddy S. Latex allergy. Am J Fam Pract 1998;57:93-100.
Natural latex from the rubber treeHeveabrasiliensisis an allergen in persons with significant cumulative latex exposure, such as those in the health care and rubber industries, as well as those undergoing repeated surgeries, especially if they undergo surgeries early in life. Symptoms of latex allergy may progress rapidly and unpredictably to anaphylaxis. The prevalence of latex allergy has increased as the use of rubber gloves in health care settings has increased. Airborne latex particles that adhere to the cornstarch used to powder gloves are a significant cause of respiratory symptoms and a source of sensitization. Once an individual has become sensitized, he or she may experience allergic symptoms when exposed to any product containing latex. Diagnosis is made initially by the history. Latex-specific IgE testing and skin prick testing may confirm the suspicion. The most effective strategy in the treatment of latex allergy is avoidance; however, there is a large group of sensitized people who have not been identified and who do not recognize that their symptoms are caused by latex allergy. Physicians caring for latex-sensitive persons must act as their advocates in building awareness of the problem and developing protocols for their safe care. Latex-sensitized persons should be educated about the latex content of common objects.-