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Previous research failed to show that the angiotensin II antagonist losartan at 50 mg per day was as effective as captopril in reducing mortality in patients with heart failure after myocardial infarction. This raised the question of whether this new class of drugs may be substituted for ACE inhibitors in treating these high-risk patients.

Angiotensin II Antagonist as an Alternative to an ACE Inhibitor for Heart Failure after Myocardial Infarction