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A study from Harvard University in Boston indicates that marijuana and tricyclic antidepressants don’t mix. In four adolescents with attention-deficit hyperactivity disorder who were on tricyclic antidepressants who smoked marijuana, there were "clinically significant adverse effects." Those effects included cognitive changes, delirium, and tachycardia, which are consistent with reactions to toxic doses of marijuana. The researchers advise educating patients and their families about the dangers of combining any type of drug used to treat mental illness and "street drugs" such as marijuana.