DDP Details

Recruiting for the Diabetes Prevention Program (DDP) is now closed and randomization is in progress, to be complete by the end of May.

Expected population:

  • 3,000 people with impaired glucose tolerance considered at high risk for developing Type 2 diabetes to participate for 2 2/3 years, to be followed up for 3 1/3 to 6 years.
  • All participants have impaired fasting plasma glucose between 95 and 125 mg/dl or a two-hour post-load plasma glucose of 140-199 mg/dl.

Target populations:

  • Half the study participants will be members of ethnic minorities:
  • African-Americans, Hispanics, Native Americans, Asian-Americans or Pacific Islanders.
  • Half the study participants will be women.
  • One-fifth will be over the age of 65.
  • Most will be overweight (BMI of 24, 22 for Asian-Americans) and over 35.

Three treatment plans:

  • Intensive lifestyle interventions including weight reduction of at least 7%.
  • Standard lifestyle recommendations plus placebo.
  • Standard lifestyle recommendations plus metformin.

Source: National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) of the National Institutes of Health in Bethesda, MD.