Recruiting for the Diabetes Prevention Program (DDP) is now closed and randomization is in progress, to be complete by the end of May.
- 3,000 people with impaired glucose tolerance considered at high risk for developing Type 2 diabetes to participate for 2 2/3 years, to be followed up for 3 1/3 to 6 years.
- All participants have impaired fasting plasma glucose between 95 and 125 mg/dl or a two-hour post-load plasma glucose of 140-199 mg/dl.
- Half the study participants will be members of ethnic minorities:
- African-Americans, Hispanics, Native Americans, Asian-Americans or Pacific Islanders.
- Half the study participants will be women.
- One-fifth will be over the age of 65.
- Most will be overweight (BMI of 24, 22 for Asian-Americans) and over 35.
Three treatment plans:
- Intensive lifestyle interventions including weight reduction of at least 7%.
- Standard lifestyle recommendations plus placebo.
- Standard lifestyle recommendations plus metformin.
Source: National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) of the National Institutes of Health in Bethesda, MD.