DDP Details
DDP Details
Recruiting for the Diabetes Prevention Program (DDP) is now closed and randomization is in progress, to be complete by the end of May.
Expected population:
3,000 people with impaired glucose tolerance considered at high risk for developing Type 2 diabetes to participate for 2 2/3 years, to be followed up for 3 1/3 to 6 years.All participants have impaired fasting plasma glucose between 95 and 125 mg/dl or a two-hour post-load plasma glucose of 140-199 mg/dl.
Target populations:
Half the study participants will be members of ethnic minorities:African-Americans, Hispanics, Native Americans, Asian-Americans or Pacific Islanders.
Half the study participants will be women.
One-fifth will be over the age of 65.
Most will be overweight (BMI of 24, 22 for Asian-Americans) and over 35.
Three treatment plans:
Intensive lifestyle interventions including weight reduction of at least 7%.Standard lifestyle recommendations plus placebo.
Standard lifestyle recommendations plus metformin.
Source: National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) of the National Institutes of Health in Bethesda, MD.
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