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In a multi-institutional cooperative effort, Rebbeck and colleagues followed the course of 105 women with either BRCA1 or BRCA2 germline mutations who had elected bilateral mastectomy as a breast cancer preventive measure. Only 2 cases of breast cancer developed in this group of operated patients compared with 184 cases in the control group, demonstrating a remarkable risk reduction of > 90%.

Prophylactic Mastectomy and the Prevention of Breast Cancer in BRCA1/2 Carriers