The MIRACLE trial
MIRACLE Studies’ Inclusion and Exclusion Criteria
The MIRACLE trial
Patient inclusion criteria
ª NYHA Class III or IV
ª QRS duration >/= 130 ms*
ª Ejection fraction <35%
ª Left ventricular end-diastolic dimension >/= 55 mm
ª Stable medical regimen** for at least one month
ª If taking beta-blockers, stable regimen for at least three months
Patient exclusion criteria
ª Unstable angina or acute MI
ª Coronary artery bypass graft (CABG) or percutaneous transluminal coronary angioplasty (PTCA) within the past three months
ª Prior pacing systems or pacing indications
ª Existing implantable cardioverter defibrillator (ICD)
ª Chronic atrial arrhythmias
ª Life expectancy < 6 months for reasons unrelated to heart failure
The MIRACLE ICD trial
Patient inclusion criteria
ª NYHA CLASS II, III, or IV
ª QRS duration > 130 ms
ª Ejection fraction < 35%
ª Left ventricular end-diastolic dimension >/= 55 mm
ª Stable medical regimen
ª If taking beta-blockers, stable for 3 months
ª Indicated for an ICD
Patient exclusion criteria
ª Unstable angina
ª CABG
ª Chronic atrial arrhythmias
* ms=milliseconds
** Including at least ACE inhibitors or an ACE inhibitor substitute, unless contraindicated or not tolerated by the patient.
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