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A case-control study of women in the Nurses’ Health Study Cohort showed that lower melatonin secretion is independently associated with a higher risk of developing type 2 diabetes. There is a physiologic basis for this finding since melatonin has a role in glucose metabolism and lack of melatonin is associated with increased insulin resistance.

Will We be Giving Melatonin to Prevent and Treat Type 2 Diabetes?