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Herpes simplex virus encephalitis (HSE) is the most common cause of sporadic fatal viral encephalitis. Although the mortality and morbidity of HSE has been significantly reduced due to early antiviral therapy, even after treatment, about 35% of patients have severe neurological sequelae or even death.

Autoantibodies to N-methyl-D-aspartate Receptor Found in Some Adults with Herpes Simplex Encephalitis: Are They Significant?