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Fit elderly patients benefit at least to the same extent from palliative chemotherapy with 5-FU as younger patients. Infusional 5-FU was shown to be more effective than bolus 5-FU in both age groups. Therefore, standardized palliative chemotherapy should generally be offered to elderly patients and they should not be excluded from clinical trials.

Efficacy of 5-Fluorouracil-Based Chemotherapy in Elderly Patients with Metastatic Colorectal Cancer: A Pooled Analysis of Clinical Trials