Aspirin resistance and enteric coating

Could "aspirin resistance" be due to enteric coating? The concept of aspirin resistance is very controversial with some experts suggesting that it does not exist. A new study suggests that enteric coating of aspirin may be partially responsible for "pseudoresistance." Researchers recruited 400 healthy volunteers who were then screened for their response to a single, oral dose of 325 mg immediate-release or enteric-coated aspirin. Variable absorption caused nearly half of those taking enteric-coated aspirin to have apparent resistance (49%), while this was not seen in any of the subjects taking immediate-release aspirin. On re-exposure, all of those with variable absorption responded to aspirin. The authors conclude that the study failed to identify a single case of true aspirin resistance, but pseudoresistance, reflecting delayed and reduced drug absorption, complicates enteric-coated but not immediate-release aspirin (Circulation published online Dec. 4, 2012. doi: 10.1161/CIRCULATIONAHA.112.117283). This study seems to contradict the concept that up to 40% of the population is "aspirin resistant." There is a suggestion that the concept of aspirin resistance has been touted by the manufacturers of expensive brand-name aspirin substitutes. This study may question the wisdom of the routine use of enteric-coated aspirin, especially given that enteric coating has very little benefit with regard to gastrointestinal protection.