Here are criteria for GP IIb/IIIa inhibitors

The following are indications and contraindications for glycoprotein IIb/IIIa inhibitors:

Indications:

1. For the treatment of patients with acute coronary syndrome (Unstable Angina with Non-Q- Wave Myocardial Infarction) with chest pain more than 10 minutes in duration within 24 hours of presentation, with at least one of the following findings:

• Electrocardiogram changes showing: ST depression >0.5 mm, ST elevation between 0.6 mm and 1 mm, or T-wave inversion > 1.0 mm.

• Elevated cardiac enzymes, isoenzyme of creatine kinase with muscle and brain subunits, or troponin.

2. Patients undergoing percutaneous coronary intervention.

Contraindications:

1. A history of bleeding diathesis, or active abnormal bleeding within the previous 30 days.

2. Uncontrolled severe hypertension: systolic > 200 mm/hg, or diastolic > 110 mm/hg.

3. Major surgery within six weeks.

4. History of stroke within 30 days, or any history of hemorrhagic stroke.

5. Platelet count < 100,000.

6. Dependence on renal dialysis.

7. For patients with a serum creatinine > 2, the dosage should be reduced per prescribing recommendations.

8. Assess patient for warfarin and/or excessive nonsteroidal anti-inflammatory drug usage.

Source: St. Jude Medical Center, Fullerton, CA.