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Over the past couple of decades, molecular genetic and mutational analysis research in nonvertebrate systems such as the worm and fruit fly have yielded important information on genetic signals, enzymes, and transitional regulators. Although this information is important for understanding the molecular events in invertebrate systems, many features of patterning and morphogenesis in vertebrates are distinct and require study in vertebrate models. The zebrafish model is one vertebrate model currently available that has several advantages, including early embryonic patterning, nervous system development, and aspects of cell fate and lineage determination.
The National Institutes of Health has issued a program announcement inviting researchers interested in advancing mutagenesis screening in the zebrafish model to detect and characterize genes, pathways, and phenotypes of interest in development, aging, organ formation, behavior, and disease processes, including cancer. This program announcement uses the modular grant and just-in-time concepts. Applications and funds are distributed through the RO1 process with grants issued in amounts of $250,000 per year in modules of $25,000. All foreign, domestic, public, private for profit, and non-profit organizations, including universities, hospitals, and research institutions, are eligible. There are three deadlines per year: June 1, Oct. 1, and Feb. 1. More information on this program announcement is available at: http://www.grants.nih.gov/grants/guide/pa-files/PA-01-070.html.
Metals in Medicine
The National Institutes of Health has issued a program announcement to encourage research that bridges inorganic chemistry and medicine. The focus of this program is to elucidate the mechanism by which organisms transition medal ions and the roles of these metals in cellular regulation and cell-cell signaling. A secondary area of interest is the interaction of synthetic organic complexes with living systems and their components. This announcement encourages collaboration between chem-ists, biochemists, and cell and molecular biologists. All foreign, domestic, public, private for profit, and non-profit organizations, including universities, hospitals, and research institutions, are eligible. This program announcement will use the existing RO1 research project grant mechanism with awards made in the amount of up to $250,000 per year in $25,000 modules. There are three deadlines per year: June 1, Oct. 1, and Feb. 1. More information on this grant is available at: http://www.grants.nih.gov/grants/guide/pa-files/PA-01-071.html.