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Source: Martell N, Luque M. J Clin Hypertens. 2001;3:218-223.
In middle age and beyond, both hypertension and benign prostatic hyperplasia (BPH) become increasingly common. Treatment of normotensive BPH patients can usually be accomplished using alpha-blockers without problematic episodes of hypotension. For hypertensive BPH patients, there has been some concern that addition of doxazosin to the antihypertensive regimen might produce hypotension or other untoward effects. This study evaluated the effect of 2-4 mg QD doxazosin added to the regimen of patients who had a achieved a diastolic blood pressure < 95 on nonalpha blocker monotherapy.
Patients (n = 2363, Spanish men > age 40) were followed for 14 weeks, and evaluated by a quality-of-life scale, prostatism symptom scale, blood pressure measurement, and recording of adverse events.
Doxazosin treatment resulted in a mean blood pressure reduction of 10.7/6.1 over baseline treatment with
an ACE inhibitor, calcium channel blocker, or diuretic. Favorable effects for prostatism scores were consistently seen. Symptoms of dizziness, vertigo, hypotension, or syncope were seen uncommonly (2.7%, 0.4%, 0.8%, 0.3%, respectively). Martell and Luque conclude that addition of an alpha-blocker to the treatment regimen of hypertensive BPH patients is generally effective and well tolerated.
The Therapeutics & Drug Briefs were written by Louis Kuritzky, MD.
In the August 2001, issue on page 5 in the article, "Pioglitazone Improves Lipid Profiles More Effectively than Rosiglitazone," the sentence in the second paragraph, "Mean cholesterol, triglyceride, and low-density lipoprotein (LDL) cholesterol levels decreased in the pioglitazone group by 44.7%, 11.3%, and 7.3% but increased 8.4%, 38.4%, and 8.1%, respectively, in the rosiglitazone group," should have read ". . .cholesterol levels decreased in the pioglitazone group by 4.7%." We regret any confusion this may have caused.
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