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Dial and colleagues point out that<I> Clostridium</I> <I>difficile</I> is the most common form of nosocomial infectious diarrhea in the Western world, apparently increasing in frequency, severity, and consequential health care costs (more than $1 billion in the United States annually).

Risk of Clostridium difficile Diarrhea Among Hospital Inpatients Prescribed Proton Pump Inhibitors