Cryptococcosis in Previously Normal Adults: NIH Study Seeking Participants

Investigators led by John Bennett at the National Institute of Allergy and Infectious Disease are seeking participants in a 5-year study that will follow the course of disease in previously healthy patients with cryptococcosis who developed the disease for no identifiable reason.

Individuals 18 years and older with a positive culture of Cryptococcus neoformans who are not HIV infected and have no other condition predisposing to cryptococcosis (such as high-dose corticosteroid therapy, sarcoidosis, or a blood cancer) may be eligible for this study. Candidates who test positive for HIV infection may not participate.

Participants will have a physical examination, medical history, routine blood tests and assessment of disease activity upon entering the study. Patients who may have active cryptococcosis will also have a lumbar puncture and additional blood tests. Following the initial evaluation, patients receiving treatment for cryptococcosis will come to the NIH Clinical Center as needed to manage their disease, typically no less than every 3 months. Other patients will be seen every 6 to 12 months. The visits will include a medical history, physical examination, and blood and urine tests.


John E. Bennett, M.D.
National Institute of Allergy and Infectious Diseases (NIAID)
National Institutes of Health
Building 10
Room 12C103B
10 Center Drive
Bethesda, Maryland 20892
(301) 402-0198