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The authors note a paucity of literature on early (0-48 hours of ventilation and ICU admission) sedation practices and their impact on outcomes; thus they performed this multicenter prospective cohort study with the hypothesis that early sedation is associated with delirium, time to extubation, and hospital and 180-day mortality.

Lie Still, Sleep Becalmed: The Effects of Deep Sedation in the First 48 Hours of ICU Care