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The recently published IST-3 trial has stimulated great interest in the expanded use of intravenous thrombolysis (IV rtPA). Wardlaw and colleagues assessed all of the evidence from published randomized trials for IV rtPA in acute ischemic stroke using a meta-analysis.

Meta-analysis of All Randomized Trials Supports the Benefits of Intravenous Thrombolysis for All Patients Up to 6 Hours