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An elderly man diagnosed with rheumatoid arthritis was prescribed methotrexate by his doctor. Although he immediately began to experience symptoms of methotrexate toxicity, the doctor failed to take the patient’s complaints seriously and refilled the prescription for another month. The man continued to experience the same symptoms and, two weeks later, he was rushed to an emergency department for treatment. The ED physicians were unable to prevent the man’s death, which they attributed to methotrexate toxicity.

Legal Review & Commentary - Improper prescribing leads to toxicity and death: $2.2 million settlement in Missouri