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Post-surgical treatment of node-positive breast cancer with chemotherapy has been shown to reduce tumor recurrence and mortality, but the value of such therapy in geriatric populations has not been firmly established. In the current analysis of 4 large Cancer and Leukemia Group B trials spanning 25 years, there was no association between age and disease-free survival or cancer mortality. However, overall survival was significantly worse for older women, presumably from causes other than breast cancer.

Age and Adjuvant Breast Cancer Treatment: Equal Dose, Equal Response