Compared to women who undergo breast cancer screening with mammography alone, those receiving MRI exams experience a two- to fivefold increased rate of core and surgical biopsy. However, the biopsies have a lower cancer yield rate than mammography alone.
In this study, routine endocervical curettage (ECC) among women age 30 and older detected CIN 2 or worse in 14.4% of cases with higher likelihood of detection among women with high-grade squamous intraepithelial lesion, ASC-H, positive HPV 16 infection, or high grade colposcopic impression. The additional yield of ECC over lesion-directed ectocervical biopsies decreased with each additional biopsy.
In this retrospective cohort study of premenopausal women with abnormal uterine bleeding, obesity, as opposed to age, was the most significant predictor of complex hyperplasia or cancer on endometrial biopsy.
A comparison of breast biopsy diagnosis by clinical pathologists found a 75% concordance with a consensus-derived expert diagnostic interpretation. Concordance was lowest with the diagnosis of atypical, with under-diagnosis noted in 35% of cases.