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Articles Tagged With: cgrp

  • CGRP Antagonists: What Is Their Role in Headache Therapy?

    Migraine is a highly prevalent and debilitating condition that causes significant impairment in quality of life. Preventive therapy for migraine is indicated when migraine attacks interfere with quality of life or are frequent and debilitating. The ability to prevent migraine with pharmacologic therapy has long been a goal of both patients and their physicians. The ideal preventive (prophylactic) migraine treatment should be effective, safe, and well tolerated, with few or no contraindications, few or no drug interactions, safety in pregnancy and breastfeeding, and dosed in a manner to ease adherence.

  • Atogepant for Migraine Prevention

    Atogepant, an oral small-molecule inhibitor of the calcitonin gene-related peptide pathway, administered once daily, effectively reduced migraine days in the preventive treatment trial of migraine over a period of 12 weeks.

  • Oral Calcitonin Gene-Related Peptide Antagonist for Prevention of Migraine

    Atogepant, an oral calcitonin gene-related peptide (CGRP) antagonist, was shown to be effective and safe for migraine prevention. This adds an additional CGRP antagonist to the growing arsenal of such medications, both oral and parenteral, for both prevention and treatment of migraine.