Articles Tagged With: Epilepsy
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Post-Traumatic Epilepsy and the Risk of Dementia
A subset of people with head injury will develop post-traumatic epilepsy (PTE). This prospective cohort study demonstrated a 4.5-fold increased risk of dementia in those with PTE compared to people without head trauma or epilepsy, and that this risk exceeds that observed in people with head trauma or epilepsy alone.
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What Is the Best First-Line Treatment for Young Women with Generalized Epilepsy?
Valproate is a highly efficacious drug for treating idiopathic generalized epilepsy (IGE) but is not an option for many young women because of known teratogenic risks. This retrospective, multicenter study examined women with IGE who were treated initially with either levetiracetam or lamotrigine monotherapy, demonstrating superior efficacy of levetiracetam, although exclusively in women with juvenile myoclonic epilepsy.
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Somatic Variants in Ras/Raf/MAPK Pathway Play a Role in Mesial Temporal Lobe Epilepsy
Eleven somatic variants enriched in the hippocampus were detected in a group of patients with drug-resistant mesial temporal lobe epilepsy (MTLE). Most somatic variants are mutations in the Ras/Raf/mitogen-activated protein kinase (MAPK) pathway. Overactivation of the Ras/Raf/MAPK pathway was detected in MTLE with somatic variants.
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Management of Seizures in the Emergency Department
While most seizures will be brief and self-limited, prolonged seizure activity and status epilepticus represent high morbidity and mortality presentations. This review aims to summarize the best available evidence on seizure evaluation, classification, and acute management.
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Can Artificial Intelligence Help Us to Choose the Best Anti-Seizure Medicine?
A new deep learning artificial intelligence algorithm was able to identify the most effective initial drug to treat newly diagnosed epilepsy, compared to the physicians’ clinical judgment. The algorithm required prospective, carefully collected clinical data for its success.
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Epilepsy: The Hidden Side Effect of Bariatric Surgery
The benefits of weight loss procedures are numerous, but a recently published paper reveals a long-term side effect clinicians and patients should heed.
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Researchers Explore Connections Between Epilepsy and Postpartum Anxiety, Depression
Clinicians should monitor for signs of depression among patients with epilepsy who are pregnant or patients who are thinking about conceiving.
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Risk Factors and Outcomes for Post-Traumatic Seizures After Moderate to Severe Traumatic Brain Injury
Using data collected from an Australian registry, a population-based cohort study identified risk factors for early post-traumatic seizures (EPS), associated morbidity and mortality, and contribution to development of post-traumatic epilepsy (PTE). EPS were associated with significant in-hospital morbidity, poorer outcomes, and increased risk of mortality at 24 months of follow-up. Patients with EPS had a higher risk of developing PTE.
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Risk Factors and Outcomes for Post-Traumatic Seizures After Moderate to Severe Traumatic Brain Injury
Using data collected from an Australian registry, a population-based cohort study identified risk factors for early post-traumatic seizures (EPS), associated morbidity and mortality, and contribution to development of post-traumatic epilepsy (PTE). EPS were associated with significant in-hospital morbidity, poorer outcomes, and increased risk of mortality at 24 months of follow-up. Patients with EPS had a higher risk of developing PTE.
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Post-Surgical Seizure Outcomes in MRI-Positive Focal Cortical Dysplasia
This comprehensive meta-analysis of the surgical outcomes for drug-resistant epilepsy caused by focal cortical dysplasia demonstrated an excellent result with post-surgical freedom from seizures in 70% of patients followed for more than 24 months.