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Articles Tagged With: Neuropathy

  • Hepatitis E and Neuropathy

    In this prospective case-control study of patents with neuralgic amyotrophy, Guillain-Barré syndrome, and Bell’s palsy, an association with acute hepatitis E infection was demonstrated only with neuralgic amyotrophy.

  • Nitrous Oxide-Induced Neuropathy

    Nitrous oxide-induced neuropathy presents with a rapidly progressive sensorimotor neuropathy that may mimic Guillain-Barré syndrome. The pattern of clinical weakness and progression, as well as electrophysiological features, can help to rapidly distinguish the two disorders.

  • Involvement of the Peripheral Nervous System in Neurolymphomatosis

    Lymphoma that presents with peripheral neuropathy is a challenging diagnosis. Diagnosis and treatment often are delayed, but they can be facilitated by early consideration and imaging with fluorodeoxyglucose-positron emission tomography. Early diagnosis and hematologic treatment may be effective.

  • The Neural Pathways of Pain Treatment Response in Small-Fiber Neuropathy

    Pain in peripheral neuropathy, referred to as neuropathic pain, is thought to result from overexpression of pain receptors, regeneration of hypersensitive nerve sprouts, and denervation hypersensitivity of neurons in the sensory ganglia. Additionally, activation of the pain pathways appears to induce secondary structural and functional changes in the brain that contribute to pain perception, persistence, and response.

  • The Effect of Peripheral Neuropathy in Parkinson’s Disease on Gait and Balance

    In this cohort study of 99 patients with Parkinson’s disease (PD), 40% were found to have peripheral neuropathy, with the majority meeting criteria for small fiber neuropathy. Gait and balance were worse in PD patients with neuropathy compared to those without.

  • Electrodiagnostic Features of Vasculitic Neuropathy

    Electrophysiological studies of vasculitic neuropathy indicate that the best discriminators of vasculitis vs. other axonal neuropathies are the side-to-side differences between the same bilateral nerves. When the diagnosis is uncertain, nerve biopsy may be definitive.

  • Pyridoxine (B6) Toxicity in Chronic Idiopathic Axonal Polyneuropathy

    In a careful prospective collection of features of chronic idiopathic axonal neuropathy, with retrospective ascertainment of vitamin B6 levels in the blood, the investigators reported there was no significant correlation between the severity of neuropathy symptoms and plasma B6 levels.

  • Incidence, Prevalence, and Long-Term Consequences of Small Fiber Neuropathy

    Small fiber neuropathy (SFN), a subtype of peripheral neuropathy characterized by painful distal neuropathic pain and autonomic symptoms, is increasing in incidence. SFN associated with diabetes and other causes is more likely to progress to large-fiber polyneuropathy and have faster deterioration and higher disability compared to slow progression with idiopathic SFN. Glucose impairment, obesity, and elevated triglycerides are modifiable risk factors of idiopathic SFN. Although major disability and neurologic impairment are uncommon in this slowly progressive condition, higher mortality and cardiovascular events are noted in patients with SFN.

  • What Is Focal CIDP?

    Chronic inflammatory demyelinating polyneuropathy (CIDP) usually is diagnosed in patients who have a generalized disorder. However, there are focal syndromes that have been observed and diagnosed under different names that meet many of the clinical and electrodiagnostic criteria of CIDP and may be referred to as “focal” CIDP.

  • Genetic Biomarkers of Immunoglobulin Response in Patients with CIDP

    Nearly 25% of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) have a poor response to intravenous immunoglobulin treatment. Variations in the PRF1 and FCGR2B genes in CIDP patients offer insights into the heterogenous treatment response.