Articles Tagged With: amyloid
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Posterior Cortical Atrophy: An Important Variant of Alzheimer’s Disease
This is the first comprehensive international study of patients with posterior cortical atrophy, including clinical, biomarker, and pathology data from 1,092 patients. These patients present at a younger age, have a very high prevalence of amyloid positivity on cerebrospinal fluid studies and positron emission tomography, and 94% had autopsy evidence of Alzheimer’s disease.
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Neurodegeneration Biomarkers in Patients with Subjective Cognitive Complaints
In individuals with subjective cognitive decline, multiple biomarkers of neurodegeneration were found to add predictive values beyond amyloid and tau biomarkers.
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Researchers Find Lower Amyloid Levels in Patients on Blood Sugar Control Drug
An investigation reveals an interesting trait among those taking a common diabetes management solution. -
Transthyretin Amyloidosis and Neuropathy
Wild-type transthyretin amyloidosis, referred to as “senile” amyloidosis previously, usually occurs in the aging population and affects the peripheral nerves and the heart. Usually, neurological symptoms precede cardiac symptoms.
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Plasma Phospho-Tau217 Is a Promising Alzheimer’s Disease Biomarker
Validation and replication of findings in the use of the blood biomarker phospho-tau 217 for the diagnosis of Alzheimer’s disease holds out the possibility for a new era in the early diagnosis and treatment of this debilitating illness.
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Cardiac Constriction vs. Cardiac Restriction
The five Mayo Clinic Doppler echocardiographic criteria for the diagnosis of constrictive pericarditis (CP) were tested in a group of surgically confirmed CP compared to a group of cardiac biopsy proven amyloid restrictive cardiomyopathy. Interventricular septal bounce and an elevated mitral annular medial e’ were found to be the most accurate criteria, especially if used together.
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Dementia Update
Dementia is a common and growing problem that is associated with significant caregiver burden and immense cost. A growing focus on disease prevention and management of risk factors in mid-life is vital to attempt to mitigate the daunting impact of this illness on patients, caregivers, and the healthcare system as a whole.
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Use of Amyloid PET Imaging for Diagnosis of Dementia
The use of amyloid positron emission tomography scanning to assist in accurate diagnosis of patients with symptoms of cognitive impairment as well as frank dementia results in a change of diagnosis in at least 25% of patients.
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Isolated Amyloid Myopathy
Isolated amyloid myopathy is a rare disorder that can be distinguished from systemic amyloidosis with myopathy by clinical, biochemical, and muscle biopsy histologic criteria.
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How Useful is Amyloid PET Imaging in the Diagnosis of Dementia?
In a prospective, observational study in multiple centers in Italy, amyloid PET imaging was shown to be negative in 35% of patients who met clinical criteria for a diagnosis of Alzheimer’s disease.