There are some signs of progress in drug-resistant infections in pediatrics, suggesting that antibiotic stewardship efforts may be having an effect and fewer broad-spectrum agents are being used on this important patient group, the Centers for Disease Control and Prevention reports.
In patients with gram-negative rod bacteremia, patients receiving seven days of antibiotics had similar 90-day mortality, readmission rates, and rates of recurrent bacteremia as patients receiving 14 days of antibiotic.
A combination of public health, antibiotic stewardship, and infection control efforts over the last six years have managed to beat back the devil of multidrug-resistant bacteria. Yet all still hangs in the balance.
Relative to vancomycin or metronidazole treatment of recurrent Clostridioides difficile infection, treatment with fecal microbiota transplantation is associated with a reduced risk of bloodstream infection, shorter hospital length of stay, and improved survival.
In a retrospective cohort study of 350 patients, the combination of a beta-lactam antibiotic plus daptomycin was not superior to beta-lactam monotherapy in patients with bacteremia due to methicillin-susceptible Staphylococcus aureus.
Though there has been tremendous progress in antibiotic stewardship efforts over the last decade, a broad and demanding array of research and action is needed if the rise of drug-resistant bacterial infections is to be stemmed, the Society for Healthcare Epidemiology of America reports in a new white paper.