By shortening the duration of antibiotic therapy, a procalcitonin-guided protocol decreased the rate of infection-associated adverse effects, decreased costs, and reduced mortality in patient with sepsis.

A population-based cohort study showed that exposure to antibiotics during the first two years of life is associated with increased rates of subsequently developing asthma, allergic rhinitis, atopic dermatitis, attention deficit hyperactivity disorder, celiac disease, and obesity.

Compared to in-person visits, virtual visits were associated with improved antibiotic prescribing practices for women with uncomplicated urinary tract infections.

Community-acquired pneumonia is a common cause for hospital admission. This article serves to summarize new updates in the definition, prognosis, and treatment, specifically of bacterial, severe community-acquired pneumonia.

In a multicenter, cluster-randomized crossover trial, researchers compared standard precautions vs. contact isolation for preventing acquisition of ESBL-producing Enterobacterales (ESBL-E) in non-intensive care unit settings. Contact isolation did not decrease the number of hospital-acquired ESBL-E cases, which questions the value of the practice.

Approximately one-tenth of asymptomatic patients with Clostridioides difficile colonization went on to develop disease. A wide range of antibiotic exposures represent a significant risk.

A retrospective cohort study found that broad-spectrum antibiotics were unnecessarily prescribed to patients with community-onset sepsis and was associated with worse outcomes and higher mortality.

Clostridioides difficile infections are declining in U.S. hospitals, as measures over the last decade to reign in antibiotic use and improve infection control appear to be working.