In a randomized, controlled trial of adult patients with bone or joint infections, researchers found oral antibiotic therapy was noninferior to intravenous therapy based on treatment failure at one year.
Postmenopausal hormone therapy may reduce the risk of developing age-related hyperkyphosis, commonly known as a “Dowager’s hump,” and the benefit from hormone therapy use in early menopause may provide long-term benefit.
A systematic review of randomized, controlled trials of calcium supplementation found only small non-progressive increases in bone mineral density. This supports the clinical conclusion that supplementation alone is insufficient to prevent fracture risk.
Two hundred sixty-five children with culture-proven acute bone or joint infections were studied. All patients received 2-4 days of IV antibiotics followed by PO antibiotics. Clinical outcomes and resolution of inflammatory biomarkers were the same whether the patient had positive blood cultures or not on admission.