Articles Tagged With: candidiasis
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Rezafungin Injection (Rezzayo)
Rezafungin can be prescribed to treat candidemia and invasive candidiasis in patients age 18 years or older with limited or no alternative options.
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Ibrexafungerp for Vulvovaginal Candidiasis
The authors of a randomized clinical trial compared one day of oral ibrexafungerp with placebo for women with vulvovaginal candidiasis (VVC). They found ibrexafungerp to be safe and effective, with mild diarrhea the most common adverse event. Ibrexafungerp differs mechanistically from azoles and appears to be a promising new treatment for VVC.
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Ibrexafungerp Tablets (Brexafemme)
Ibrexafungerp can be prescribed to treat adults and post-menarchal pediatric females with vulvovaginal candidiasis.
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Throat Infections Part I: Low-Acuity Disease Entities
Sore throats are common! Being able to differentiate low-acuity self-limited infections from those processes that may result in sepsis or life-threatening airway compromise is critical. The author, in this two-part article, reviews the range of pathologies that may present with a sore throat. -
Isavuconazole vs. Caspofungin for Candidemia
In a large, randomized, double-blind, multicenter clinical trial, researchers found that isavuconazole did not meet the primary endpoint of noninferiority compared to caspofungin for candidemia and invasive candidiasis.
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Empirical Antifungals in the ICU — Probably Not Helpful
Two hundred sixty non-neutropenic ICU patients with clinical evidence of sepsis receiving broad-spectrum antibiotics and known to be colonized by Candida species were randomized to micafungin for 14 days vs. placebo. Empirical micafungin therapy did not increase invasive fungal infection-free survival at 28 days.
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Oral Fluconazole During Pregnancy Increases Risk for Spontaneous Abortion
A nationwide cohort study from Denmark found a significantly increased risk of spontaneous abortion associated with oral fluconazole usage. Caution with this medication during pregnancy is advised.