Accumulating evidence suggests that immune dysregulation by glioblastoma cells induces tumor-associated edema and that disruption of this tumor-immune interaction may represent a novel strategy to reduce cerebral edema in glioblastoma.
In this comprehensive review of studies comparing treatments for cerebral cavernous malformations, there were no randomized or blinded outcome trials, and the most effective treatment remains uncertain.
This article will explore the subtle and enigmatic presentations of stroke. These patients often will present with nonspecific symptoms, such as vision problems, headache, a subtle language deficit, dizziness, or amnesia.
Time is of the essence in management of intracranial hemorrhage and subarachnoid hemorrhage. The longer it takes to make the diagnosis and initiate treatment, whether it is surgical intervention or simply aggressive primary stabilization, the greater the risk to the patient regarding both morbidity and mortality.
Acute stroke reperfusion therapies have led to significant reduction in the morbidity and mortality associated with ischemic strokes due to large vessel occlusion. This article will discuss the prevalence, mechanism, diagnosis, and treatment options of acute ischemic stroke due to large vessel occlusion.
This article will outline the presentation of sudden onset headache in the ED, with a focus on important history and physical examination findings, associated differential diagnoses, and the appropriate workup and treatment of each condition.
Based on review of data from 14 patients with adult cerebral X-linked adrenoleukodystrophy who were treated with hematopoietic stem cell transplantation, the authors suggested that this might be an intervention that potentially could have long-term benefits and recommended further studies to evaluate this therapy.
Cerebral microbleeds, as visualized on gradient-echo or susceptibility-weighted MRI, are considered markers of bleeding-prone cerebral microvessels and constitute a significant and independent predictor of future intracerebral hemorrhage.
Tissue hypoxia after traumatic brain injury occurs in a widespread manner in the brain, including areas that appear structurally normal. Moreover, cerebral tissue hypoxia appears to occur independent of ischemia with areas of no overlap, implying a microvascular etiology.