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Articles Tagged With: cerebral

  • Leriglitazone for the Treatment of Adrenomyeloneuropathy

    A 96-week trial of leriglitazone to slow the progression of symptoms in adrenomyeloneuropathy did not meet the primary endpoint. However, post-hoc analyses revealed a beneficial effect in patients treated earlier in their disease course.

  • Intensive Blood Pressure Control May Augment Cerebral Blood Flow

    Patients with hypertension were randomized to intensive vs. standard blood pressure control and underwent baseline and follow-up cerebral perfusion imaging. Intensive blood pressure treatment was associated with improved cerebral perfusion over time.

  • Multiple Sclerosis and Vascular Disease

    Researchers evaluated the presence and pathological significance of extracranial systemic and cerebral small vessel disease in patients with multiple sclerosis (MS) compared to healthy controls. MS patients exhibited less systemic vascular disease and more small vessel disease in the brain vs. controls.

  • Multiple Sclerosis and Vascular Disease

    This postmortem study of multiple sclerosis (MS) patients evaluated the presence and pathological significance of extracranial systemic and cerebral small vessel disease in patients with MS compared to healthy controls. MS patients had less systemic vascular disease and more small vessel disease in the brain compared to controls.

  • Immune Cell Infiltration Drives Cerebral Edema in Glioblastoma

    Accumulating evidence suggests that immune dysregulation by glioblastoma cells induces tumor-associated edema and that disruption of this tumor-immune interaction may represent a novel strategy to reduce cerebral edema in glioblastoma.

  • Stereotactic Radiosurgery for the Treatment of Cerebral Cavernous Malformations

    In this comprehensive review of studies comparing treatments for cerebral cavernous malformations, there were no randomized or blinded outcome trials, and the most effective treatment remains uncertain.

  • Stroke: The Subtle, Atypical, and Enigmatic

    This article will explore the subtle and enigmatic presentations of stroke. These patients often will present with nonspecific symptoms, such as vision problems, headache, a subtle language deficit, dizziness, or amnesia.

  • Subarachnoid Hemorrhage and Intracranial Hemorrhage

    Time is of the essence in management of intracranial hemorrhage and subarachnoid hemorrhage. The longer it takes to make the diagnosis and initiate treatment, whether it is surgical intervention or simply aggressive primary stabilization, the greater the risk to the patient regarding both morbidity and mortality.

  • Acute Ischemic Stroke Due to Large Vessel Occlusion

    Acute stroke reperfusion therapies have led to significant reduction in the morbidity and mortality associated with ischemic strokes due to large vessel occlusion. This article will discuss the prevalence, mechanism, diagnosis, and treatment options of acute ischemic stroke due to large vessel occlusion.

  • Sudden Onset Headache

    This article will outline the presentation of sudden onset headache in the ED, with a focus on important history and physical examination findings, associated differential diagnoses, and the appropriate workup and treatment of each condition.