Articles Tagged With: clindamycin
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Comparing Adjuvant Clindamycin to Linezolid for Invasive Group A Streptococcal Infections
In a retrospective, single-center cohort study of patients with severe group A streptococcal infection, there was no significant difference in clinical response in those treated with adjunctive clindamycin as compared with adjunctive linezolid
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Trimethoprim Sulfamethoxazole Plus Clindamycin for Treatment of Staphylococcus aureus Endocarditis
A before-and-after intervention study compared 170 patients treated with either oxacillin IV or vancomycin IV for six weeks (plus gentamicin IV given during the first five days) to 171 patients who were treated with TMP/SMZ IV plus clindamycin IV for the first week followed by TMP/SMZ PO (without clindamycin) to complete a six-week course. Mortality and hospital length of stay were significantly less in the TMP/SMZ-treated patients.
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Vancomycin for MRSA Pneumonia Following Influenza in Children
Coinfection with methicillin-resistant Staphylococcus aureus (MRSA) in children with influenza is associated with high fatality. Data support the addition of a second anti-MRSA antibiotic to vancomycin in severely ill children.
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Clindamycin Improves Outcomes in Necrotizing Fasciitis Due to Group A Streptococcus
Using a murine model of necrotizing fasciitis, investigators determined that clindamycin inhibits key virulence factors of Group A Streptococcus, and should be given as soon as possible and at high doses to reach levels above MIC in affected tissues.
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Clindamycin vs. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Infections
Five hundred twenty-four children and adults with either cellulitis or abscesses larger than 5 cm (smaller for children) were enrolled in a multisite prospective study of clindamycin vs. trimethoprim-sulfamethoxazole dosed for 10 days. Cure rates did not differ between the treatments, and rates of adverse events were similar in the two groups.