Articles Tagged With: clostridioides
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The Use of Proton-Pump Inhibitors and the Risk of Acquiring Community-Associated Clostridioides difficile Infection
A nationwide cohort study of adults in Denmark found that proton-pump inhibitor (PPI) use was associated with a moderately increased risk of community-associated Clostridioides difficile infection, and the risk remained elevated up to one year after PPI treatment had stopped. -
Does the Addition of IV Metronidazole Improve Outcomes of Severe Clostridioides difficile Infection?
These studies indicate that the addition of intravenously administered metronidazole in the treatment of severe Clostridioides difficile infection is unwarranted.
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Clostridioides difficile: Risk Factors for Disease
Approximately one-tenth of asymptomatic patients with Clostridioides difficile colonization went on to develop disease. A wide range of antibiotic exposures represent a significant risk.
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Differentiating Clostridioides difficile Infection from Chronic Carriage in Patients with Diarrhea Through Host Inflammatory Markers
Investigators compared levels of inflammatory markers in patients with Clostridioides difficile infection (CDI) to those who were colonized with it. Several markers appeared to be able to distinguish true CDI, although a gold standard definition of CDI is needed.
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Colonization With Clostridioides difficile Frequently Leads to a Misdiagnosis of Healthcare-Associated Infection
A prospective cohort study from a single institution revealed 27% of patients diagnosed with healthcare-associated Clostridioides difficile infection were colonized with the same isolate on admission.
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Clostridioides difficile Infection: Fecal Microbiota Transplantation vs. Antibiotics
Relative to vancomycin or metronidazole treatment of recurrent Clostridioides difficile infection, treatment with fecal microbiota transplantation is associated with a lower risk of bloodstream infection, shorter hospital length of stay, and improved survival.
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Fulminant Clostridioides difficile Infection: Hold the IV Metronidazole?
The combination of oral vancomycin and intravenous metronidazole is not superior to vancomycin alone in the treatment of fulminant infection due to Clostridioides difficile.
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Recurrent Clostridioides difficile Infection: Better Outcomes With Fecal Microbiota Transplantation Than With Antibiotics
Relative to vancomycin or metronidazole treatment of recurrent Clostridioides difficile infection, treatment with fecal microbiota transplantation is associated with a reduced risk of bloodstream infection, shorter hospital length of stay, and improved survival.
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Preventing Clostridioides difficile Infections: Early De-escalation of Antipseudomonal Antibiotics
Early discontinuation of empirically administered antipseudomonal antibiotics may prevent many cases of Clostridioides difficile infection.