Articles Tagged With: clostridium
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Probiotics Do Not Prevent C. difficile Infection in Hospitalized Patients
A retrospective cohort study from a single California hospital found the administration of probiotics to patients receiving antibiotics did not reduce the incidence of healthcare facility-onset Clostridioides difficile infection.
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Oral Vancomycin Is the Most Cost-effective Treatment for the First Recurrence of Clostridium Difficile Infection
The authors of a pharmacoeconomic study comparing bezlotoxumab plus oral vancomycin, oral vancomycin alone, and fidaxomicin found that oral vancomycin alone was the most cost-effective regimen to treat the first recurrence of Clostridium difficile infection.
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Probiotics for the Primary Prevention of Clostridium difficile Infection
The authors of a before-and-after intervention study and a meta-analysis found that probiotics reduce the incidence of Clostridium difficile infection (CDI). The strategy seems to work best in hospital settings where the incidence of CDI is ≥ 5% and for patients receiving two or more antibiotics.
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Extended-pulsed Dosing of Fidaxomicin vs. Standard-dose Vancomycin for Clostridium difficile Infection
A randomized, controlled, open-label clinical trial conducted at 86 European hospitals that included adults aged 60 years or older found that extended-pulsed dosing of fidaxomicin was superior to standard-dose vancomycin for sustained cure of Clostridium difficile infection and resulted in fewer disease recurrences.
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Prevention of Clostridium difficile Recurrence by Orally Administered Fecal Microbiota Transplantation
Fecal microbiota transplantation orally administered in capsules was non-inferior to administration by colonoscopy.
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Restricting Fluoroquinolone Use Reduces Clostridium difficile Infection More Than Infection Control Methods
An observational study from England showed that restricting fluoroquinolone use reduced incidence of Clostridium difficile infection more than would be predicted by improved infection control methods alone.
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Bezlotoxumab Injection (Zinplava)
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Fecal Transplant vs. Oral Vancomycin Taper for Recurrent Clostridium difficile Infection
In a small randomized, controlled trial that compared fecal microbiota transplant (FMT) administered by enema to a six-week oral vancomycin taper, FMT was not more effective for patients with recurrent Clostridium difficile infection.
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Clostridium difficile Infection — Back to the Future
SYNOPSIS: This study provides strong evidence that the diagnosis of Clostridium difficile infection (as opposed to colonization) should be made on the basis of evidence of toxin production, not the mere presence of the organism as detected by glutamate dehydrogenase testing or the presence of toxin genes.
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Clostridium difficile Infection — Back to the Future
This study provides strong evidence that the diagnosis of Clostridium difficile infection (as opposed to colonization) should be made on the basis of evidence of toxin production, not the mere presence of the organism as detected by glutamate dehydrogenase testing or the presence of toxin genes.