Articles Tagged With: congenital
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Maternal, Fetal, and Infant Implications of a Positive Syphilis Screening During Pregnancy
Although syphilis screening during pregnancy is effective in identifying maternal syphilis, it is not without consequences. False-positive syphilis testing can result in unwarranted antibiotic therapy; re-screening based on risk is not always consistent, and among pregnant women who truly test positive to syphilis, treatment is not always optimized to prevent congenital syphilis.
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The Association Between SSRIs and Congenital Anomalies
In this synthesis involving 15 meta-analytic studies, four studies demonstrated an association between paroxetine use during pregnancy and increased risk of major congenital anomalies (relative risk [RR], 1.18 [95% confidence interval (CI), 1.05, 1.32] to 1.29 [95% CI, 1.11-1.49]). For all selective serotonin reuptake inhibitors (SSRIs), the RR for major anomalies (1.10 [95% CI, 1.03, 1.16] to 1.27 [95% CI, 1.09, 1.47]) and cardiac defects (1.06 [95% CI, 0.94, 1.18] to 1.36 [95% CI, 0.61, 3.04]) were increased. This meta-analysis suggests an increased risk of cardiac and major anomalies with SSRI use, but the results should be interpreted with caution, since all included studies were meta-analyses of retrospective cohort studies.
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Diagnosis and Management of Infants With Critical Congenital Heart Disease in the Emergency Department
Critical congenital heart disease (CCHD) is a significant cause of morbidity and mortality in children. When children with undiagnosed congenital heart disease (CHD) present acutely, the challenge of diagnosis and the importance of timely management can be daunting for any physician in an emergency setting. The children with the highest morbidity and mortality from critical congenital heart disease are infants younger than 1 year of age.
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What Can Clinicians Do to Combat Increase in Congenital Syphilis Rates?
Cases of congenital syphilis have more than doubled since 2013, according to the Centers for Disease Control and Prevention. All pregnant women should visit a healthcare provider as soon as possible to be tested for syphilis, but one test may not be enough to catch all cases.
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Mice, Mutations, and Microcephaly: The Evolving Pathogenesis of Congenital Zika Syndrome
Approximately five years ago, a single gene mutation altered Zika virus, making it able to target neuronal progenitor cells and cause what we now know as congenital Zika syndrome with microcephaly and ocular abnormalities.
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‘Talk. Test. Treat.’ Aimed at Syphilis
There are more reported cases of primary and secondary syphilis in the United States now than there have been in more than 20 years. The Centers for Disease Control and Prevention has issued a call to action to reverse the trend.
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Intrauterine Zika Virus Infection — Not Just Microcephaly at Birth
Manifestations of intrauterine Zika infection may not be clinically apparent at birth, warranting the use of early neuroimaging and careful follow-up.
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Infectious Disease Alert Updates
TB Quant Problematic in Leprosy; Trapping Flu Particles; An Old Scourge Revisited: Congenital Syphilis
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Congenital syphilis on rise — What you can do
Are you testing your pregnant patients for syphilis at the first prenatal visit and treating them if infected? If not, it’s time to step up your efforts. An analysis from the CDC shows that after years of decline, the number of congenital syphilis cases reported in the United States increased between 2012 and 2014.