Drug delivery platform will release medication for monthly dosing
August 30, 2019
Although lowering side effects plays an important role in oral contraceptive compliance, one of the biggest challenges for patients is adhering to the daily schedule of the pill. Forgetting one to three pills per cycle is a frequent problem among 15-51% of users, particularly among adolescents. Lyndra Therapeutics has received a $13 million grant from the Bill & Melinda Gates Foundation and is setting out to remove the daily pill compliance challenge. The company is in early development of a monthly oral contraceptive to provide women with a discreet, noninvasive, reversible contraception option.
Scientists are now investigating a nonhormonal monthly ring (Ovaprene) as a potential contraceptive. The device involves a permeable mesh in the center of the ring that creates a partial barrier to sperm and locally acting spermiostatic agents to create an inhospitable environment for sperm.
Despite guidance stating that a patient should be offered the option to begin her chosen long-acting reversible contraception birth control method at the time of the office visit rather than waiting for her next period or returning for another appointment, just 29% of clinicians say they provide same-day placement.
Early studies of a potential male contraceptive pill, which contains a modified testosterone that has the combined actions of an androgen and a progesterone, are underway. The experimental male oral contraceptive was the subject of a recent study to analyze its safety, tolerability, pharmacokinetics, and pharmacodynamics.
The American College of Obstetricians and Gynecologists has released a practice bulletin to help providers use scientific evidence to guide women with coexisting medical conditions in making the most effective choices.