A large meta-analysis showed higher consumption of eggs (eating more than one egg daily) was not associated with an increased risk of cardiovascular disease, and was associated with a lower risk of coronary artery disease.
A study of single nucleotide polymorphisms (SNP) that increase blood levels of diet-derived antioxidants in three large individual subject genetic databases did not demonstrate a relationship between SNPs and coronary artery disease.
A systematic imaging protocol of coronary angiography, optical coherence tomography, and cardiac MRI in women clinically diagnosed with myocardial infarction with non-obstructive coronary artery disease revealed a cause in 84%, with three-quarters exhibiting an ischemic etiology.
A study of the utility of a polygenetic score for coronary artery disease risk was compared to the pooled cohort equation (PCE) for determining which primary prevention patients would benefit from statin use. Only at the top 5% risk stratum did the genetic score exceed an odds ratio for coronary disease of 2. Using these data would increase statin recommendations by 4% vs. the PCE.
Researchers analyzed the MESA study to determine the comparative value of the pooled risk equation vs. CT coronary artery calcium score for determining which aspirin-naïve patients < age 70 years without overt coronary artery disease would benefit most from primary prevention with aspirin. They found a calcium score of > 100 was superior for this determination.
Researchers identified subjects with no known coronary artery disease drawn from a large international, multicenter registry of coronary CT angiography. The authors demonstrated those with a high density of calcium plaques experienced the fewest events, suggesting high-density calcium plaques are stable.
Researchers identified subjects with no known coronary artery disease drawn from a large international, multicenter registry of coronary CT angiography. Subjects were divided into matched pairs with and without a subsequent acute coronary syndrome event. The authors demonstrated those with a high density of calcium plaques experienced the fewest events, suggesting high-density calcium plaques are stable.
The gut microbial metabolite trimethylamine N-oxide (TMAO) is a predictor of coronary artery disease (CAD). Long-term changes in TMAO is a predictor of CAD and speaks to the benefits of a plant-based diet to prevent heart disease.
An analysis of the PROMISE trial by age showed that cardiovascular death or myocardial infarction was predicted by a positive stress test in patients with symptoms suggesting myocardial ischemia who were >age 65 years, but only CT angiography or a calcium score was predictive in symptomatic patients < age 65 years.
In three subgroups of coronary artery disease patients with atrial fibrillation, apixaban plus a P2Y12 inhibitor provided superior safety and similar efficacy outcomes as treatment with warfarin, aspirin, or both for six months.