In a large, diverse cohort of Medicare patients hospitalized for heart failure exacerbations, almost half were on medications known to exacerbate heart failure; more than one-third were on these agents at discharge.
The use and abuse of methamphetamine is a worsening global health problem that may be underestimated in light of the current opioid epidemic. Methamphetamines result in sympathetically mediated agitation and in psychiatric symptoms. Clinicians should be knowledgeable about the recognition and treatment of these disorders, as well as about the other complications, including arrhythmias, cerebrovascular accidents, seizures, dental issues, and systemic and local infections.
Early research is focusing on a capsule that can deliver a week’s worth of HIV drugs in a single dose. If confirmed in advanced research, such an option could allow patients to stay compliant with the dosing regimen required to fight the virus successfully.
A new business model is emerging in which pharmaceutical companies buy the rights to a drug, then raise the price dramatically. Often, the drugs are produced by one manufacturer, with few or no alternatives.