Adult patients experiencing sepsis with hypotension but who did not meet the definition of septic shock received a median of 800 mL of intravenous fluid prior to initiation of norepinephrine 0.05 mcg/kg/min as a non-titratable infusion. Patients in this early vasopressor group had much lower odds of failing to achieve their primary outcome of adequate mean arterial pressure and tissue perfusion when early norepinephrine was provided.
This article will focus primarily on the important aspects of acute decompensated heart failure in the emergency setting. The authors will include a brief synopsis of noncardiogenic pulmonary edema to highlight key principles in the diagnosis and management.
This double-center, double-blind, randomized, controlled trial compared the efficacy of pyridostigmine bromide vs. fludrocortisone and demonstrated that pyridostigmine bromide was not as effective as fludrocortisone. The authors also provided evidence for the efficacy of fludrocortisone in treating neurogenic orthostatic hypotension.